SCOTTSDALE, Ariz.–Another day, another new player.So it goes in Giants camp, where new president of baseball Farhan Zaidi is working diligently to add quality depth while maintaining optimal roster flexibility.Thus far, none of the new players the Giants have acquired are 26-year-old superstar free agents. But a few are expected to help the club improve immediately, including Friday’s signee, switch-hitting infielder Yangervis Solarte.“To have not just a switch-hitter, but a guy who has …
The Institute for Creation Research is gearing up for a multi-year GENE project to look for evidence for design (and against evolution) in the genome. They may not need to work very hard. Secular scientists, by continuing to find things not all that helpful for neo-Darwinism, are doing yeoman’s work for them. While the few pro-evolutionary articles usually focus on mere sources of variation in the genome as fodder for natural selection (such as this Molecular Biology and Evolution paper on retrotransposons), or try to infer phylogeny by molecular comparisons, they usually do not attempt to apply the variations to actual functions except at a trivial level (see 04/06/2006). Most genetics papers, by contrast, are finding degrees of order, regulation and coordinated action in the cell that challenge gradualistic explanations. Here are some examples from the past two months:Rapid Gradualism? New Scientist reported that many human genes must have “evolved recently” – even as recently as within the last 15,000 years. While some of the 700-odd genes they studied, they claim, appear to have been targets of natural selection after the human line diverged millions of years ago, “some of the newly identified genes fall into categories not previously known to be targets of selection in the human lineage, such as those involved in metabolism of carbohydrates and fatty acids.” (Ker Than at Live Science took this to mean humans are still evolving.)Transcript Complexity: PLoS Genetics had a special issue about the complexity of the “transcriptome,” the body of all transcribed DNA. The lead article’s teaser sounds pretty dramatic:Besides revealing staggering complexity, analysis of this collection is providing an increasing number of novel mRNA classes, expressed pseudogenes, and bona fide noncoding variants of protein-coding genes. In addition, new types of regulatory logic have emerged, including sense-antisense mechanisms of RNA regulation. This high-resolution cDNA collection and its analysis represent an important world resource for discovery, and demonstrate the value of large-scale transcriptome approaches towards understanding genome function.After the human genome was deciphered, scientists were puzzled by the seeming small number of genes – about 30,000. Now, it appears that the exons of genes can be assembled and reassembled in a modular way by alternative gene splicing (09/23/2005), yielding many protein variants from one gene. Not only that, the DNA “negative” on the opposite (antisense) strand can play a role in regulating the gene. These articles speak as if a whole new world of complexity is coming to light.Who Regulates the Regulators? Nature March 23 reported on important pathways that regulate the fate of RNA transcripts of genes. David Tollervey wrote in the introduction,Cells alter their rates of mRNA transcription to change mRNA levels, and so rates of protein synthesis, in response to many stimuli. To adjust mRNA levels, cells must be able to rapidly get rid of normal mRNAs that were previously synthesized (turnover). In fact, different mRNAs differ radically in their rates of degradation, and this is subject to both metabolic and developmental regulation. In addition, cells must guard against the synthesis of abnormal mRNAs (surveillance), which can produce defective, potentially toxic, protein products.The mechanisms described in the article, including “go/no-go” checkpoints unveil a higher level of complexity beyond the information contained in the genes themselves.Ring Job: The copies during cell division must be accurate. Many protein parts cooperate to ensure high levels of quality control. Nature reported March 23 on a discovery of a ring that slides along the microtubules in the all-important stage of separation of the paired chromosomes.High Fidelity Proofreading: Albertson and Preston talked about quality control of the DNA copying process in an article in Current Biology March 23:Proofreading is the primary guardian of DNA polymerase fidelity. New work has revealed that polymerases with intrinsic proofreading activity may cooperate with non-proofreading polymerases to ensure faithful DNA replication.This means that some polymerases (copy machines) have better fidelity than others, but they cooperate to ensure a precision product. A low-fidelity machine might be necessary to get past a bad break, for instance – like when a heftier wrench is needed (09/19/2005). How good is the system? Orders of magnitude better than a human copyist:Normal cells replicate their DNA with remarkable fidelity, accumulating less than one mutation per genome per cell division. It is estimated that replicative DNA polymerases make errors approximately once every 104-105 nucleotides polymerized. Thus, each time a mammalian cell divides approximately 100,000 polymerase errors occur, and these must be corrected at near 100% efficiency to avoid deleterious mutations. This is accomplished through the combined actions of… exonucleolytic proofreading and post-replication mismatch repair.New Uses for Junk: “Just because we don’t know what it does, doesn’t mean it’s really junk,” said Christina Cheng of non-coding DNA (U of Illinois) in an interview for Radio Netherlands. Her work has found that arctic cod produce antifreeze proteins (05/13/2004) from non-gene regions of DNA, “a gene that appears to have evolved [sic] out of this DNA that supposedly serves no purpose.” Yet “Preserving this rubbish [sic] seems an inefficient use of time and resources. Evolutionary pressures [sic] should favour creatures with less junk DNA” said author Marnie Chesterton. “So its conservation may be because it has functions that we don’t yet know.” Cheng said, “conventional thinking assumes that new genes must come from pre-existing ones because the probability of a random stretch of DNA somehow becoming a functional gene is very low if not nil.” (see online book).No More Mr. Simple Guy: Embley and Martin in Nature March 30 had some words for those who tell simplistic tales about an ancient prokaryote being co-opted as a mitochondrion in the first primitive eukaryote (see 08/06/2004):The idea that some eukaryotes primitively lacked mitochondria and were true intermediates in the prokaryote-to-eukaryote transition was an exciting prospect. It spawned major advances in understanding anaerobic and parasitic eukaryotes and those with previously overlooked mitochondria. But the evolutionary gap between prokaryotes and eukaryotes is now deeper, and the nature of the host that acquired the mitochondrion more obscure, than ever before.Modular Programming: An article in Nature March 30 by 37 European scientists found an exquisite example of modular programming – in yeast. They even spoke machine language:The richness of the data set enabled a de novo characterization of the composition and organization of the cellular machinery. The ensemble of cellular proteins partitions into 491 complexes, of which 257 are novel, that differentially combine with additional attachment proteins or protein modules to enable a diversification of potential functions. Support for this modular organization of the proteome comes from integration with available data on expression, localization, function, evolutionary conservation, protein structure and binary interactions. This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling.Question is, what evolutionist would want to model 257 novel proteins and 491 complexes, all tightly regulated and “evolutionarily conserved” (i.e., unevolved)?Pas de Deux: We know that we have two copies of each gene, one from the father and one from the mother, but which copy leads and which follows? As in marriage, this process is surprisingly complicated. Spilianakis and Flavell explored this important question in a Perspectives article in Science April 14. They showed how the dance involves the help of many servants:The genetic information of higher organisms is encoded in DNA that is not randomly dispersed within the cell nucleus, but is organized with nucleoproteins into different kinds of chromatin, the building blocks of the chromosomes. Each chromosome resides in a specific region of the nucleus when the cell is not undergoing cell division, and usually genes that are actively being expressed loop out from their condensed chromatin territory and localize to a region of transcriptional activity. These “transcription factory” areas are thus abundant with protein factors that initiate and regulate gene expression.The dance gets really wild, but not chaotic, when a gene on one chromosome is regulated by factors on another chromosome.The Parallel Universe of RNA: The title of this article in PNAS hints at previously-unknown complexity: “Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes.” This article was discussed in more detail here 04/27; see also the 09/08/2005 entry.Guardian Spirits: In today’s Nature (May 4), Paul Megee titled an article, “Molecular biology: Chromosome guardians on duty.” He begins, “Curiously, in cell division the proper separation of chromosomes into daughter cells needs set periods when they are stuck together. So how do they come apart at the right time and place? Their ‘guardian spirits’ intercede.” Reminding the reader of the importance of high fidelity in cell division, he discusses work by Japanese scientists who “describe how proteins known as shugoshins – Japanese for ‘guardian spirits’ – and an associated regulatory enzyme temporally and spatially control the removal of cohesins from chromosomes.” Cohesins keep the chromosomes together while they line up on the spindle, but need to be broken at the right time (03/04/2004) in a coordinated way – thanks to their guardian spirits.These are just samples pouring out of the secular literature on genomics. Clearly, a great deal more choreographed complexity is being found in the nucleus than Watson and Crick could have imagined when the genetic code first began to be deciphered. Perhaps creationists will need to do little more than compile and cite.Darwinists are fond of storytelling with glittering generalities. When challenged, they retreat into accusations that anything other than 100% pure materialistic Darwinism is religion, not science, and use other shifty-feet tactics. The answer is to pile on the evidence. These articles are the tip of a truckload of data-rich, fact-filled laboratory studies that shout design instead of evolution. Let’s rid secular science of its bad storytelling habit, and let the evidence speak for itself. The Darwinists are sliding downhill with an avalanche of data racing down against them. Perhaps a better cartoon of their predicament is to picture Wiley Coyote hanging by his fingers on a cliff. Jonathan Wells, by debunking the icons of evolution, is like the Road Runner lifting Mr. Coyote’s fingers one at a time, while the genetic evidence is like Tweety Bird simultaneously piling weights on his feet. Pretty soon he fall down go boom.(Visited 12 times, 1 visits today)FacebookTwitterPinterestSave分享0
Established in 2001, Translate.org.za works to provide South Africans with useful open source software in their mother tongue.Janine ErasmusTranslate.org.za is a non-profit organisation that translates free open source software, such as internet browser Firefox and e-mail client Thunderbird, into South Africa’s 11 official languages. Two of the company’s products have been selected for internet search engine Google’s Summer of Code 2008.The Summer of Code is a collaborative programme that brings together students and mentors from 90 countries around the world to work during the US summer holidays on free open source software products, enhancing and modifying them. Open source software can be freely modified, since the underlying code has been made available to users by the developers.Products are provided by selected mentoring organisations. Students then evaluate the products and choose those which match their skills and interests. They submit an application to work on their product of choice and if accepted, receive a stipend for their work. Applications from students may be submitted to Google from 24 March 2008.The two Translate.org.za products are Translate Toolkit and Pootle, both of which assist in language translation and localisation.Translate Toolkit is a set of tools that enables programmers to switch between various translation formats (such as OpenOffice.org formats and Mozilla formats). This simplifies the work because only one translation editor is needed for a variety of applications.Pootle is a set of online translation and translation management tools. The web interface is translated into more than 35 languages, and translations of the interface are updated live. Both projects are written in the Python programming language.Making software accessible to non-English speakersEstablished in 2001, Translate.org.za aims to empower South Africans by providing useful open source software in their mother tongue. The company believes that its solutions not only promote indigenous languages and provide practical interventions, but that they also encourage other software vendors to play a more active role in adapting their products to the requirements of those who do not speak English as a home language.According to Dwayne Bailey, director of Translate.org.za, about 80% of South Africa’s population is not fluent in English, and therefore the work is important because it allows everyone access to technology.The organisation has notched up some notable achievements in recent years. These include the translation of Firefox and Thunderbird into all 11 official South African languages, the release of the first free Afrikaans spell checker, translation of parts of the Red Hat distribution of Linux into Afrikaans, Pedi (Northern Sotho) and Zulu, and the release of free office suite OpenOffice.org in the 11 official languages.Translate.org.za has also created South Africa’s first multilingual keyboard that can display the special characters needed by the Venda, Afrikaans, Pedi and Tswana languages, as well as the DejaVu font for Venda.The organisation has garnered numerous awards for its achievements. In 2006 it won an African ICT Achiever Award for helping to make essential software accessible to more people in Africa. These awards are endorsed by the New Partnership for Africa’s Development and were established to reward individuals and organisations that have made a difference to the ICT industry in Africa.Translate.org.za also received a Pan South African Language Board award in 2007. The board promotes the equal use and enjoyment of all the official languages of South Africa. The “Multilingualism and Nation Building: eBusiness Institution of the Decade” award celebrates not only Translate.org.za’s accomplishments but also its ongoing work with universities in training students to translate software through its Translate@thon programme.The Translate@thon is a one-day translation drive held at tertiary education institutes where students and staff work intensively on translation of software.The first Translate@thon took place in 2004 at the University of Cape Town. Students and staff translated the OpenOffice.org glossary into Xhosa. A follow-up event in 2005 resulted in a fully translated version of Firefox in Xhosa.The Translate.org.za team also worked in 2005 with staff and students from the Durban Institute of Technology and the University of KwaZulu-Natal to translate Firefox into Zulu.The most recent Translate@thon was held in May 2007 at Rhodes University in the Eastern Cape on translating the campus email system into Xhosa. All work was done using Pootle.Related articlesSouth Africa onlineUseful linksTranslate.org.zaPan South African Language BoardDepartment of Arts and CultureNew Partnership for Africa’s DevelopmentAfrican ICT Achievers AwardsDurban Institute of TechnologyUniversity of Cape TownUniversity of KwaZulu-NatalRhodes UniversityGoogle
13 May 2014 A team of South African students from the University of Cape Town (UCT) has won a People’s Choice Award for their low-cost fire detection device for shack-dwellers at the annual Global Social Venture Competition at the University of California, Berkeley in the US. The project was named one of the top five initiatives worldwide and won the award in the global round in April. They competed against hundreds of entries from around the world, beating 18 finalists in the last round. The competition is one of the world’s pre-eminent social business plan competitions, providing aspiring entrepreneurs with mentoring, exposure and prize money to transform their business ideas into positive real-world projects. Khusela, which means “protect”, is an integrated alert service designed for shack-dwellers. There is a lack of fire-fighting infrastructure in South African informal settlements, where shack fires are an ongoing problem. “Our proactive early-warning system networks individuals within communities and with the authorities to mitigate the loss of life and property caused by shack fires, a global human tragedy,” said electrical engineer Francois Petousis, co-founder of Khusela, who is currently undertaking a Masters degree in inclusive innovation at the UCT Graduate School of Business (GSB). “There are a billion shack/slum-dwellers across the globe, and that is set to soar to 1.4-billion by 2020,” Petousis said in a statement issued by the school. Khusela is based on Petousis’s honour’s thesis, and the Khusela team consists of electrical engineering lecturer Samuel Ginsberg, economist and Khusela co-founder David Gluckman, community researcher Emily Vining, industrial designer Max Basler, and electrical engineer Paul Mesarcik. The team entered the international competition through the UCT Student Social Venture Programme, which is hosted by Bertha Centre for Social Innovation and Entrepreneurship and the UCT GSB Net Impact Chapter. The UCT programme was created to improve the quality and performance of African universities at global social business plan competitions. The Bertha Centre is the southern African regional outreach partner for the social innovation competition, and hosts the initial round of the competition. The director of the Bertha Centre, Dr François Bonnici, said that African teams had not featured in global competitions in the past because they lacked support and sponsorship. “Our firm belief in setting up the UCT Student Social Venture Programme at the GSB was that student social ventures of global standards were being developed in South Africa, not just at UCT, that deserve our support,” Bonnici said. Khusela is not the first South African team that has passed through the programme. Last year, graduates the Reel Gardening team won both the social innovation prize and the Hult Prize London regional competitions, beating 50 other universities, and was one of six teams globally to compete in the prestigious Clinton Global Initiative. UCT GSB director Walter Baets said social innovation was increasingly gaining focus, not only in business but at business schools. “Especially in our emerging market situation, we need to encourage innovative thinking and the generation of new ideas to meet the unique challenges of our environments.” Petousis said going to Berkeley was extremely exciting for the team. “After all 18 finalist teams presented to the judges on our first day of competition in Berkeley, Khusela was named as one of the six teams to go onto the next stage of the finals, which was a fantastic achievement considering the range of powerful teams who had presented their social enterprises that day.” The next step for the Khusela team will include making use of recent funding received from the Technology Innovation Agency and UCT to fully develop, test and roll out about 2 000 devices in a pilot project in South Africa. “We received excellent feedback from the judges specifically because our numbers were reasonable and justified, we have significant scalability and a strong plan to do so, the social impact scales as the business does, so there is a significant market which we have great opportunity to serve and the value created is significant,” Gluckman said. Petousis said just being a part of the competition was inspiring. “All these people are devoting their lives to discovering how we can create a world where you get paid to do good, where business can function to support that which really matters and makes a difference to humans. The room was far from what traditionally is the mood of a competition. The ethos was of support and collaboration, because at the core, everyone was there to serve a bigger purpose than their own.” Gluckman added that there was lots of scope out there for other aspiring social innovators to get involved. “Get out and engage with the community that you wish to serve. Get off the computer, stop writing the business plan, put down the pen and paper and get into your market and find out. In social impact work, it is critical to know with as close to 100% certainty that there is truly a need. That’s true for any business, but specifically in the social impact space where resources are scarce and challenges are huge.” SAinfo reporter and University of Cape Town
Start Free Trial Already a member? Log in Sign up for a free trial and get instant access to this article as well as GBA’s complete library of premium articles and construction details. William Rose is fun to listen to. The author of a landmark book, Water in Buildings, Rose is a research architect at the University of Illinois at Urbana-Champaign and a widely respected building scientist.Rose’s speaking style is discursive, meandering, hesitant, and occasionally poetic. He shares historical anecdotes that sometimes seem only remotely relevant to his topic. Eventually, however, he sews together a patchwork quilt with a unified theme.Rose gave the keynote address, “A Building Science To-Do List,” at a building envelope conference I recently attended in Florida (the Thermal Performance of the Exterior Envelopes of Whole Buildings XIII International Conference). Looking ahead to retirement, Rose was ready to bequeath his list to the younger building scientists in the audience.“I received a warm invitation from André Desjarlais to speak here,” said Rose. “He said something like, ‘Bill Rose, you’re old.’ It was a liberating and inspiring thing to hear. So I’ve been thinking about the things I wanted to get done in building science. I may not get these things done — I may have to pass these things on to you.” Studying building corners The first item on Rose’s list is simple: we need a better understanding of corners. Energy modeling is often one-dimensional — as, for example, when a scientist describes the temperature profile across an insulated wall. Some energy programs are capable of modeling convective loops, and are therefore two-dimensional. But any consideration of building corners requires a three-dimensional approach.“Corners are some of the most interesting parts of the building,” said Rose. “I did a survey of freeze-thaw damage on brick buildings. Not much damage shows up in the field of the brick except where the brick is… This article is only available to GBA Prime Members
Liverpool Lovren could return for Liverpool despite death threat scare, says Klopp Joe Wright Last updated 2 years ago 00:28 11/1/17 FacebookTwitterRedditcopy Comments(0) Getty Liverpool Jürgen Klopp Philippe Coutinho Sadio Mané Liverpool v Maribor Maribor UEFA Champions League The defender was the target of a threatening message aimed at his family, with his manager pledging to speak with him about the issue before Wednesday Liverpool boss Jurgen Klopp hopes to have Philippe Coutinho and Dejan Lovren available for Wednesday’s Champions League clash with Maribor.An adductor problem kept Coutinho out of the 3-0 Premier League win over Huddersfield Town on Saturday, while Lovren was forced to withdraw from the starting XI moments before kick-off due to a thigh concern.The centre-back was heavily criticised for his performance in the 4-1 loss to Tottenham and revealed on Instagram his family had been the target of a death threat in recent days , prompting suggestions he could be rested for Maribor’s visit to Anfield. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player But Klopp, who will speak to Lovren about the message aimed at his family, hopes to have both in the squad for a key game in Group E, provided they can come through training on Wednesday unscathed.”I am not 100 per cent sure. They are both much better but whether they will be ready, I don’t know at this moment,” Klopp told a news conference.”We have to see. We have a [training] session at 5pm and we will see who will be involved. I hope for both.”If they will not train, especially in Dejan’s case, that does not mean he cannot play. In Dejan’s case if he could train tonight [Tuesday] and tomorrow, that would be enough.“We have a few little things, Alberto [Moreno] had a cramp, Joe [Gomez] felt [something] a little bit. So we were really careful in the last few days.”If a player is playing, then he must be at 100 per cent. I will speak to the medical department. I don’t think about rotation, I think about a 100 per cent spot-on team.””I don’t think about rotation. I think about having a 100 per cent spot on team.”Watch live and free: https://t.co/kT7mkv3qO5 pic.twitter.com/mds3gD8X7J — Liverpool FC (@LFC) October 31, 2017 Klopp also confirmed Sadio Mane and Adam Lallana are making good progress in their recovery from injury, although he does not expect either to return this week.Mane has been out with a hamstring injury since the beginning of the month and England midfielder Lallana has yet to play this season after injuring his thigh in August.”It looks good. Sadio had this morning a clearing session before he returns to training,” he said. “Now he’s not in the squad so [Wednesday] is a down day, then on Thursday he should be in training.”Adam will be part of team training in the international break. Both of them are in a good way, but not good enough to involve them tomorrow or at West Ham.”Liverpool recorded an emphatic 7-0 win over Maribor in the reverse fixture and another win this week would put them in a strong position to qualify for the last 16.But Klopp insists he will not take anything for granted, despite the easy nature of their meeting in Slovenia.”I have had too many football games in my life to feel relaxed before a game like this. If we win it 1-0, I’m fine. We want three points, a clean sheet and a better position,” he added. Subscribe to Goal’s Liverpool Correspondent Neil Jones’ weekly email bringing you the best Liverpool FC writing from around the web
The Qld Junior State Cup will be held at Glasshouse from July 7-9. The divisions are boys and girls Under 11, 13, 15 and 17. Keep an eye on the Queensland website for all the nomination forms and conditions of entry. Touch SA has loads of big news this week…they are holding a level 1 coaching course throughout June/July. It’s a great opportunity to expand your basic knowledge and skills in coaching and to help those that you coach…if you’re interested check out all the info on www.touchsa.com.au Peter Topp is on annual leave until April 26th, in the interest of his email inbox please try to not send him too many emails, especially large ones, as he will be unable to answer them for several days. Touch SA’s best Open players battled it out over the weekend for the Mitchell Cup, with the Mariners taking both the Mens and Womens Open titles over the Rangers. For all the results and the SA Open Squads that were named following the competition, check out www.touchsa.com.au The 2006 NSW Affiliate Conference is being held this weekend, 22-23 April at the Bankstown Sports Club. To check out the program or for more information, visit the NSW Touch website. ACT Touch are looking for officials for their Under 18 National Championships sides, check out www.acttouch.com.au for more info. Keep tuned to the TFA website for a great story out of Touch SA….Game Development Officer Andy Crawford has just traveled Pitjantjatjara Lands (Pit Lands) in the North West of SA, for a week long development program. The Northern NSW Eagles and Hunter Western NSW Hornets are both holding upcoming annual general meetings. Check out the dates, times and venues at www.nswtouch.com.au The Sporting Images photographs from the 2006 NTL are up on www.sportingimages.com.au for viewing and purchase. Just go to the website and find the Touch section and scroll through the pictures. It’s a great opportunity to purchase a souvenir or perhaps a present for a family member, friend or coach. Touch Football Queensland have announced their sides for the 2006 State of Origin competition, check out www.qldtouch.com.au. Welcome to another edition of Sixty Seconds in Touch, it’s the post Easter edition and after several days of bunking down with roast dinners and endless Easter eggs, we’re all back at work ready to go for another week…The Fox TV coverage on the National Touch League package has been well received, with countless compliments received in the office for the standard of the coverage, commentary and footage. Check out the TFA website later this week for a full story on the coverage. Touch SA are also running an Affiliate Training and Information day on Sunday August 27, from 10am-3pm. There is no cost to the affiliate and is open to all. The day will cover several different topics, for the full list check out the Touch SA website. The TFA tipping competition is heating up, with ‘Richo’ sitting on top of the NRL standings with ‘Smitya’ also on 29 points. Richo, if that’s you Glen Richardson Touch Football Queensland Development Officer, well…we’re after you. In the AFL competition ‘Mexican’ is holding a two point lead after round 3, but with their results going backwards each week a large group are on Mexican’s tail and next week’s tips look like they could provide some difficult choices. Dubbo is hosting the 2006 NSW Touch Country Championships on 27-28 May at Lady Cutler Reserve. For more information visit the NSW Touch website. In Victorian news, a chilly wind did nothing to discourage teams fighting for the prize money at the 2006 Victorian Country Knockout. For the full story, check out www.victouch.com.au Remember, if you have any info for the weekly edition of Sixty Seconds in Touch please email firstname.lastname@example.org
In Thursday’s first contest of the second round of the NCAA Tournament, No. 3 seed Notre Dame held off a wild rally from No. 14 seed Northeastern to prevail, 69-65. The Irish, more known for their offensive prowess, had to lock down defensively on the Huskies’ final possession to eke out the victory. Following the game, head coach Mike Brey kicked off his locker room speech by clarifying just how important a victory it was for the team.Here’s a clip from our locker room after our 2nd-round NCAA win. Stay tuned to @WatchND for full video. #NotDoneYet pic.twitter.com/5a1HuQW7Uz— Notre Dame MBB (@NDmbb) March 19, 2015Notre Dame has had a tough time advancing in the NCAA Tournament over the years, so this was a big hump for the program. How far can the Irish go?
georgia spike squad mark foxGeorgia basketball coach Mark Fox has always made it clear how much he supports the school’s football team. Saturday, he’ll be going all out, yet again, to help cheer on the Dawgs against SEC juggernaut Alabama.Friday, Fox, on Twitter, revealed that he’ll be joining the Spike Squad in the stands for the contest. The Spike Squad is notorious for wearing body paint and spiked shoulder pads to games.…& forgive me when I drip paint on you cause I’m #100%Dawg @UGASPIKESQUAD – I’m in! Time to GATA pic.twitter.com/ldchIG1e2q— Mark Fox (@coachmarkfox) October 2, 2015This isn’t the first time Fox has done this, and it probably won’t be the last. Very cool.
Related StoriesNANOLIVE‘s novel CX-A defines a new standard for live cell imaging in 96 well plates for continuous organelle monitoring in cell populationsNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Artificial intelligence can help accurately predict acute kidney injury in burn patientsDeep biological aging clocks can be used for data quality control, biological target identification and even the evaluation of the biological relevance and value of various data types and combinations. The recent perspective on the value of human data recently appeared in Cell Trends in Molecular Medicine.”Deep biomarkers of aging developed utilizing a variety of data types of aging are rapidly advancing the longevity biotechnology industry. Using biomarkers of aging to improve human health, prevent age-associated diseases and extend healthy life span is now facilitated by the fast-growing capacity of data acquisition, and recent advances in AI. They hold a great potential for changing not only aging research, but healthcare in general,” said Polina Mamoshina, Senior Scientist at Insilico Medicine. Source:InSilico Medicine, Inc.Journal reference:Zhavoronkov, A. et al. (2019) Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity.Cell Press. doi.org/10.1016/j.tips.2019.05.004 Humans are very good at guessing each other’s age using images, videos, voice, and even smell. Deep neural networks can do it better and we can now interpret what factors are most important. Very often when someone looks older than their chronological age, they are sick. A trained doctor can guess the health status of a patient just by looking at him or her. At Insilico we developed a broad range of deep biomarkers of aging that can be used by the pharmaceutical and insurance companies, as well as by the longevity biotechnology community. In this paper we describe the recent progress in this emerging field and outline a range of non-obvious applications,”Alex Zhavoronkov, Ph.D, Founder and CEO of Insilico Medicine Reviewed by James Ives, M.Psych. (Editor)Jul 4 2019There are two kinds of age: chronological age, w hich is the number of years one has lived, and biological age, which is influenced by our genes, lifestyle, behavior, the environment and other factors. Biological age is the superior measure of true age and is the most biologically relevant feature, as it closely correlates with mortality and health status. The search for reliable predictors of biological age has been ongoing for several decades, and until recently, largely without success.Since 2016 the use of deep learning techniques to find predictors of chronological and biological age has been gaining popularity in the aging research community. Advances in artificial intelligence, combined with the availability of large datasets, have led to a boom in the field, increasing the variety of biomarkers that could be considered candidates as potential age predictors. One promising development that considers multiple combinations of these different predictors could shed light on the aging process and provide further understanding of what contributes to healthy aging.In the paper titled “Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity” in Cell Trends in Pharmacological Sciences, Polina Mamoshina, Senior Scientist at Insilico Medicine, and Alex Zhavoronkov, the Founder of Insilico Medicine, summarise current findings on the main types of deep aging clocks and their broad range of applications in pharmaceutical industry.